The Center's main administrative body is its Board of Directors composed by academics and affiliates of Harvard University and the Center for Hellenic Studies. Additionally, a dedicated team of the Center’s staff members manages CHS Greece’s programs and short- and long-term projects, as they are developed based on the Center’s vision and mission.

President of the Board is Professor Richard P. Martin, and Managing Director of the Center is Dr. Christos Giannopoulos.